Journal of Engineering Sciences / Журнал інженерних наук
Permanent URI for this collectionhttps://devessuir.sumdu.edu.ua/handle/123456789/34326
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Item Influence of technological manufacturing conditions on the porosity of calcium-phosphate scaffolds(Sumy State University, 2021) Chernobrovchenko, V.S.; Дядюра, Костянтин Олександрович; Дядюра, Константин Александрович; Diadiura, Kostiantyn Oleksandrovych; Balynskyi, M.; Panda A., A.The implantation of bone substitutes depends on the material’s osteoconductive potential and the structure's porosity Porosity is a characteristic feature of most materials. The porosity of materials has a strong influence on some of their properties, both structural and functional. An essential requirement for bone scaffolds is porosity, which guides cells into their physical structure and supports vascularization. The macroporosity should be large enough and interdependent for bone ingrowth to occur throughout the entire volume of the implant. The pore size for cell colonization in bioceramics is approximately 100 μm. Pores larger than this value promote bone growth through the material. This pore size allows the flow of growth factors and cell adhesion and proliferation, allowing the formation of new bone and developing the capillary system associated with the ceramic implant. Porosity also affects the rate of resorption of ceramics: the larger the number of micropores, the higher the dissolution rate. The investigated properties were elastic moduli, ultimate strength, compressive strength, and average apparent density. The results obtained in this work are consistent with previous studies, proving the positive role of microporosity in osseointegration and bone formation.Item Formation of hydroxyapatite coatings with addition of chitosan from aqueous solutions by thermal substrate method(Sumy State University, 2017) Яновська, Ганна Олександрівна; Яновская, Анна Александровна; Yanovska, Hanna Oleksandrivna; Большаніна, Світлана Борисівна; Большанина, Светлана Борисовна; Bolshanina, Svitlana Borysivna; Kuznetsov, V.M.The aim of this investigation was obtaining of biocompatible coatings for medical implants based on biopolymer chitosan and hydroxyapatite, which is the main mineral component of bone tissue. Coatings were obtained by thermal substrate method, because it allows low temperature deposition and provides possibility to incorporate into coating structure biomolecules, unstable at high temperatures. As a way of chitosan incorporation into coating composition co-precipitation method was proposed. It allows obtaining uniform coatings with required composition and morphology. The obtained coatings were investigated by using of XRD, SEM with EDS, adhesion was tested by test-tape method. It was assigned that chitosan addition decreased hydroxyapatite crystallinity, so the range of concentrations from 0.01 to 0.1 g/L was chosen at pH = 6.5. It was determined that variation of chitosan concentrations in the initial solution influenced on morphology and structure of hydroxyapatite coatings as well as on the antibacterial properties and the use in orthopedics and dentistry. The best characteristics were obtained for hydroxyapatite-chitosan coatings deposited from solution with chitosan concentration 0.025 g/L.